Improving Image Contrast During PET

Use of Engineered Antibodies to Improve Image Contrast During PET

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Introduction

Despite promise for the use of antibodies as molecular imaging agents in PET, their long in vivo half-lives result in poor contrast and radiation damage to normal tissue. In this study we developed an approach to overcome these limitations. Specifically, we showed that the delivery of the engineered, antibody-based FcRn inhibitor (or Abdeg, for antibody that enhances IgG degradation) results in improved tumor-to-blood ratios, reduced systemic exposure to radiolabel, and increased contrast during PET. Cosequently, Abdegs have considerable potential as agents to stringently regulate antibody dynamics in vivo, resulting in increased contrast during molecular imaging with PET.


Related publications

1
IF 6.16
R. Swiercz, S. Chiguru, A. Tahmasbi, S. M. Ramezani, G. Hao, D. K. Challa, M. A. Lewis, P. V. Kulkarni, X. Sun, R. J. Ober, R. P. Mason, and E. S. Ward, "Use of Fc-engineered antibodies as clearing agents to increase contrast during PET," Journal of Nuclear Medicine, vol. 55, no. 7, pp. 1204-1207, 2014.
2
IMS
R. Swiercz, S. Chiguru, A. Tahmasbi, S. M. Ramezani, G. Hao, D. K. Challa, M. A. Lewis, P. V. Kulkarni, X. Sun, R. J. Ober, R. P. Mason, and E. S. Ward, "Use of Fc-engineered antibodies as clearing agents to increase contrast during PET," Immunology Symposium, Dallas Arboretum, Dallas, TX, May 21, 2014.

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